The series follows Vinnie Bassett, proprietor of a pop culture memorabilia store who only takes breaks to read comic books and play video games. His bachelor life comes to a halt when he assumes guardianship of his incredibly intelligent and mature nephew, Wendell. They soon find that 12-year-old Wendell may be just the parent Vinnie needs.

A loveable goofball uncle becomes the guardian of his nephew, a 12-year-old genius.

Lonely guy Fred Stoller is thrilled when his good buddy, Vinnie D'Angelo, the world's happiest agoraphobic and fattest vegetarian, comes to live with him, until Vinnie also proves to be the world's most maddening roommate.

Three cheers for compromise as quiet-as-a-mouse Sophie learns to assert herself with bossy, big-mouthed Wendell.

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